Blar i NILU Brage på forfatter "Elespuru, Rosalie K."
-
Common Considerations for Genotoxicity Assessment of Nanomaterials
Elespuru, Rosalie K.; Doak, Shareen H.; Collins, Andrew Richard; Dusinska, Maria; Pfuhler, Stefan; Manjanatha, Mugamane; Cardoso, Renato M.S.; Chen, Connie L. (Peer reviewed; Journal article, 2022)Genotoxicity testing is performed to determine potential hazard of a chemical or agent for direct or indirect DNA interaction. Testing may be a surrogate for assessment of heritable genetic risk or carcinogenic risk. Testing ... -
In vivo Mammalian Alkaline Comet Assay: Method Adapted for Genotoxicity Assessment of Nanomaterials
Cardoso, Renato; Dusinska, Maria; Collins, Andrew Richard; Manjanatha, Mugamane; Pfuhler, Stefan; Registre, Marilyn; Elespuru, Rosalie K. (Peer reviewed; Journal article, 2022)The in vivo Comet assay measures the generation of DNA strand breaks under conditions in which the DNA will unwind and migrate to the anode in an electrophoresis assay, producing comet-like figures. Measurements are on ... -
Thymidine Kinase+/− Mammalian Cell Mutagenicity Assays for Assessment of Nanomaterials
Chen, Tao; Dusinska, Maria; Elespuru, Rosalie K. (Peer reviewed; Journal article, 2022)The methods outlined here are part of a series of papers designed specifically for genotoxicity assessment of nanomaterials (NM). Common Considerations such as NM characterization, sample preparation and dose selection, ...